- Kuempers 2018: good intra-observer and excellent intra-class reproducibility of PBR measurements in ICU and ER patients; increased PBR in ICU patients compared with ER patients. PBR correlates with Mean Arterial Pressure (MAP) and with CRP and SOFA scores. Title of paper: Bedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study
- Weissgerber 2019: reproducibility of PBR measurements in pre-eclampsia patients increases when taking average of 2 or 3 measurements. Title of paper: Early Onset Preeclampsia Is Associated With Glycocalyx Degradation and Reduced Microvascular Perfusion.
- Kuempers 2019: PBR in patients correlates with plasma Syndecan-1 levels and with Atomic Force Microscope measurements of glycocalyx dimension on cultured endothelial cells exposed to patients' plasma. Title of paper:Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
- Gorshkov 2018: Increase of PBR is associated with ischemic heart disease. Title of paper: Increase in perfused boundary region of endothelial glycocalyx is associated with higher prevalence of ischemic heart disease and lesions of microcirculation and vascular wall.
Eskens 2013: Insulin increases PBR, and hyaluronidase treatment of the glycocalyx abolishes the insulin effect (figures 1C and 1D).Title of paper: Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats.
Eskens 2014: PBR is increased in response to a High Fat Diet (figure 2D) and PBR correlates with increased duration and level of plasma glucose (area under the curve of glucose) after Glucose Tolerance Test (figure 4). Title of paper: Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice.
Potter 2015: Inhibition of endothelial hyaluronan production increases PBR, which is associated with diminished glycocalyx dimension as measured with the Dextran 150kDa exclusion zone (figure 1). Title of paper: Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process.
Machin 2018: PBR increase in old mice is associated with decreased glycocalyx dimension (leukocyte passage method, figure 1), and increased PBR is associated with decreased glycocalyx dimension (as measured with electron microscopy, figure 3). Title of paper: Advanced age results in a diminished endothelial glycocalyx.