Glycocalyx Research Validation and Reproducibility Papers - Microvascular

Glycocalyx Research Validation and Reproducibility Papers

Clinical Papers

Experimental papers:

Eskens 2013: Insulin increases PBR, and hyaluronidase treatment of the glycocalyx abolishes the insulin effect (figures 1C and 1D).Title of paper: Rapid Insulin-Mediated Increase in Microvascular Glycocalyx Accessibility in Skeletal Muscle May Contribute to Insulin-Mediated Glucose Disposal in Rats.

Eskens 2014: PBR is increased in response to a High Fat Diet (figure 2D) and PBR correlates with increased duration and level of plasma glucose (area under the curve of glucose) after Glucose Tolerance Test (figure 4). Title of paper: Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet-induced obesity in mice.

Potter 2015: Inhibition of endothelial hyaluronan production increases PBR, which is associated with diminished glycocalyx dimension as measured with the Dextran 150kDa exclusion zone (figure 1). Title of paper: Perturbed mechanotransduction by endothelial surface glycocalyx modification greatly impairs the arteriogenic process.

Machin 2018: PBR increase in old mice is associated with decreased glycocalyx dimension (leukocyte passage method, figure 1), and increased PBR is associated with decreased glycocalyx dimension (as measured with electron microscopy, figure 3). Title of paper: Advanced age results in a diminished endothelial glycocalyx.

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