We will conduct a 12-month randomized, placebo-controlled study to evaluate the effect of dietary supplementation with glycocalyx precursors on endothelial function in patients with COVID-19 infection. In total 60 patients who have been hospitalized due to COVID-19 infection will be included in the study for a period of 12 months. Patients will be randomly assigned to receive the diet glycocalyx precursors supplementation or placebo for a period of four months. The primary endpoint is an improvement of the PBR, a valuable index of endothelial function after 4 months in the supplementation group compared to the placebo group. At twelve months, which is 8 months after stopping with the interventions, patients will also return for a follow-up measurement.
Brief Summary:
The food supplement Endocalyx is considered to support the endothelial glycocalyx integrity by supplying sulfated polysaccharides, anti-oxidant enzymes and additional substrates for glycocalyx synthesis. The investigators will study the effect of Endocalyx on endothelial, vascular and left ventricular myocardial function in patients with COVID-19 infection.
