Multiple clinical studies on the effectiveness of Endocalyx Pro™ and its ingredients have been either completed or are in progress.

Plus, there are many double-blind studies planned by researchers that will launch in the future. It takes years to complete these studies, and even after they are completed it can take months before the peer-reviewed research study is released to the public.

Completed Studies

Studies on Endocalyx Pro™ Ingredients

Clinical Trials Underway on Endocalyx Pro™

Study Proposals

Recommendations to Study Endocalyx Pro™

Additional Endocalyx Pro Studies

Endocalyx Pro has completed and has ongoing studies that been running since 2015. These studies are in cell cultures, animals, and in humans. The studies in humans include double-blind placebo designs. These studies are on the following health conditions and diseases:

  • COVID-19
  • Aging
  • Diabetes
  • Kidney Disease
  • Psoriasis
  • Heart Diseases
  • Sepsis

Additional studies are being written and in the approval process will be devoted to these conditions:

  • Hypertension
  • Scleroderma
  • Erectile Dysfunction
  • Emergency Room Admissions
  • Arterial Plaque Development
  • Hair Growth

Pilot Study in 13 Healthy Volunteers


Summary of Findings from Clinical Studies

6.3.2 Food supplement
A pilot study was conducted among 13 healthy volunteers receiving the Endocalyx food supplement. After 3 months, the Microvascular Health Index measured by SDF imaging improved by 31%. After 4 months, the Microvascular Health Index in the volunteers improved by 50%. This showed the beneficial effects of the food supplement on the microvasculature as it significantly increased capillary density and red blood cell filling percentage, and reduced the perfused boundary region (unpublished data, H. Vink).

Summary of Known and Potential Risks and Benefits

6.4.2 Food supplement
In the pilot study with Endocalyx, no serious adverse effects were reported. One side effect that was reported was dizziness, as the Endocalyx supplement lowered the systolic blood pressure. The supplement is already used in general practitioners’ offices in the United States and to date; no one reported any major side effects. Studies conducted with the individual ingredients also did not report any serious adverse effects. A possible side effect may be an unknown allergic reaction to one of the ingredients of the supplement. Benefits of the Endocalyx food supplement in diabetic patients remain to be established but are mainly improving the microvascular health by supporting endothelial glycocalyx function.

Read more about the Endocalyx Use Study Report here.

As stated above, it takes years to complete studies like these, and even after they are completed it can take months before the peer-reviewed research study is released to the public. As soon as results are available, we will share them publicly on this page.