Main Studies – Microvascular

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Effect of Glycocalyx-targeted Therapy on Vascular Function in Older Adults: A Randomized Controlled Trial
Citation
J Appl Physiol (1985) . 2024 May 9. doi: 10.1152/japplphysiol.00150.2024
Date
May 9, 2024
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Role of dietary interventions on microvascular health in South-Asian Surinamese people with type 2 diabetes in the Netherlands: A randomized controlled trial
Citation
Nutr. Diabetes 14, 17 (2024)
Date
April 10, 2024
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Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction
Citation
Daniel R. Machin, Daniel W. Trott, Venkateswara R. Gogulamudi, Md. Torikul Islam, Samuel I. Bloom, Hans Vink, Lisa A. Lesniewski & Anthony J. Donato
Date
February 14, 2023
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Abstract Advanced age is accompanied by arterial dysfunction, as well as a diminished glycocalyx, which may be linked to reduced high molecular weight–hyaluronan (HMW-HA) synthesis. However, […]
A Dietary Supplement Containing Fucoidan Preserves Endothelial Glycocalyx through ERK/MAPK Signaling and Protects against Damage Induced by CKD Serum
Citation
Int. J. Mol. Sci. 2022, 23(24), 15520;
Date
December 20, 2022
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Abstract (1) Damage to the endothelial glycocalyx (eGC), a protective layer lining the endothelial luminal surface, is associated with chronic kidney disease (CKD), which leads to […]
Sepsis Study Summary: Endocalyx Pro™ in animal sepsis proposal.
Date
May 13, 2022
Sepsis remains a major problem of emergency and intensive care medicine, as well as the most frequent case of death in hospitalized patients. The impairment of […]
Heparan sulfate mimetic fucoidan restores the endothelial glycocalyx and protects against dysfunction induced by serum of COVID-19 patients in the intensive care unit
Citation
ERJ Open Research 2022 8: 00652-2021; DOI: 10.1183/23120541.00652-2021
Date
May 13, 2022
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Accumulating evidence proves that endothelial dysfunction is involved in COVID-19 progression. We previously demonstrated that the endothelial surface glycocalyx has a critical role in maintenance of […]
Ways and Means of Cellular Reconditioning for Kidney Regeneration
Citation
Am J Nephrol 2022;53:96–107
Date
March 8, 2022
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The Ways and Means of Cellular Reconditioning for Kidney Regeneration study also included therapeutic interventions to preserve and repair the glycocalyx. Regarding Endocalyx Pro, the authors […]
Diabetes Study: Targeting the Endothelial Glycocalyx to Enhance Vascular Function and Exercise-Induced Vascular Adaptations in Type 2 Diabetes
Date
January 24, 2022
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The prevalence of type 2 diabetes (T2D) continues to increase in the US, with 26.8 million adults carrying a diagnosis. Importantly, T2D is widespread in the […]
Psoriasis Study Design: The effect of dietary intervention on endothelial glycocalyx integrity and microvascular perfusion in patients with psoriatic disease.
Date
January 11, 2022
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Sixty patients with psoriatic disease, who are referred to the outpatient psoriasis clinic of the Attikon University Hospital, will be randomized to receive food supplement Endocalyx […]